However, Anderlecht president Vanden Stock is not giving up on his dream of playing in the Europa League semi-finals and admits that the home leg was one of the finest European nights he has experienced at the Constant Vanden Stock Stadium.
"The same way I know what they like, I think they also know what I like".
However, it is also increasingly clear Mourinho has expected more from the Frenchman during a season when United's manager has repeatedly questioned the player's contribution.
Rashford had not scored for over six months in the Premier League before his strike against Sunderland but United's academy graduate now has three goals in his past four matches. Asked what he made of Mkhitaryan's first season, Mourinho was not entirely effusive. The same way I have to go in the direction of the players, the players have to come in my direction. Yes, I think. Do I think he can play successfully for me?
United boss Jose Mourinho has confirmed that Argentina keeper Sergio Romero will start ahead of David de Gea.
Victory saw Mourinho's men stumble a step closer to the Stockholm finale 3-2 on aggregate, but the Old Trafford quarterfinal second leg proved costly as Marcos Rojo and Zlatan Ibrahimovic sustained what appear to be serious injuries.
Pogba was the next player to miss from a golden chance, volleying over with an terrible attempt after Mkhitaryan's corner fell into his path six yards out, while Ibrahimovic lashed a shot wide after great work from Michael Carrick.
MANCHESTER UNITED were run close by this Anderlecht side but - just like their dogged win against Chelsea - they got over the line in trademark Jose Mourinho style.
But United will not need a strong league finish if they win the competiton and, on this gritty showing, it's in their grasp. Are we going to play for a 0-0? No. You can't leave him alone for a single second, you can't give him too much space to operate.
The striker burst onto the scene at Old Trafford in February 2016 with two Europa League goals against FC Midtjylland on his senior debut for the Red Devils. I can not say every match is for one or the other.
"With his experience and know-how of this knock-out phase, he is a player who can be useful".
But following a 2-1 defeat to rival Manchester City in September, Mourinho publicly criticized Mkhitaryan's performance and he wouldn't play in the Premier League again for 11 weeks.